Version 5.4
Homo sapiens Gene: EHD2
Summary
InnateDB Gene IDBG-59724.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EHD2
Gene Name EH-domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000024422
Encoded Proteins
IDBP-59726
EH-domain containing 2
IDBP-595190
EH-domain containing 2
IDBP-766239
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:47713343-47743134
Strand Forward strand
Band q13.33
Transcripts
ENST00000263277 ENSP00000263277
ENST00000538399 ENSP00000439036
ENST00000540884
ENST00000602215
ENST00000596225 ENSP00000471766
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0007596 blood coagulation
GO:0030866 cortical actin cytoskeleton organization
GO:0032456 endocytic recycling
GO:0072659 protein localization to plasma membrane
GO:1901741 positive regulation of myoblast fusion
GO:2001137 positive regulation of endocytic recycling
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
GO:0055038 recycling endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000074364
View Gene Order
ENSBTAG00000021191
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.726547
RefSeq NM_014601
HUGO
OMIM
CCDS CCDS12704
HPRD 10434
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca