Homo sapiens Gene: PRKAB1
Summary
InnateDB Gene IDBG-59969.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRKAB1
Gene Name protein kinase, AMP-activated, beta 1 non-catalytic subunit
Synonyms AMPK; HAMPKb;
Species Homo sapiens
Ensembl Gene ENSG00000111725
Encoded Proteins
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
protein kinase, AMP-activated, beta 1 non-catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:119667753-119681630
Strand Forward strand
Band q24.23
Transcripts
ENST00000229328 ENSP00000229328
ENST00000541640 ENSP00000441369
ENST00000537400 ENSP00000444816
ENST00000540121 ENSP00000439235
ENST00000545223 ENSP00000437993
ENST00000545870
ENST00000542698
ENST00000538271
ENST00000537057
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 40 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0007050 cell cycle arrest
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0010628 positive regulation of gene expression
GO:0050790 regulation of catalytic activity
GO:0051291 protein heterooligomerization
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0031588 AMP-activated protein kinase complex
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
Leptin pathway
REACTOME
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Organelle biogenesis and maintenance pathway
PKB-mediated events pathway
mTOR signalling pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
PI3K Cascade pathway
IRS-mediated signalling pathway
Regulation of Rheb GTPase activity by AMPK pathway
Insulin receptor signalling cascade pathway
IRS-related events triggered by IGF1R pathway
IRS-related events pathway
Translocation of GLUT4 to the plasma membrane pathway
IGF1R signaling cascade pathway
Signaling by Insulin receptor pathway
Regulation of AMPK activity via LKB1 pathway
Membrane Trafficking pathway
KEGG
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
PID BIOCARTA
Chrebp regulation by carbohydrates and camp [Biocarta view]
Reversal of insulin resistance by leptin [Biocarta view]
PID NCI
Direct p53 effectors
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.741184
RefSeq NM_006253 XM_005253909
HUGO
OMIM
CCDS CCDS9191
HPRD 04116
IMGT
EMBL
GenPept
RNA Seq Atlas