InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKAB1

Summary

InnateDB Gene

IDBG-59969.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKAB1

Gene Name

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms

AMPK; HAMPKb

Species

Homo sapiens

Ensembl Gene

ENSG00000111725

Encoded Proteins

IDBP-59971

protein kinase, AMP-activated, beta 1 non-catalytic subunit

IDBP-600770

protein kinase, AMP-activated, beta 1 non-catalytic subunit

IDBP-583300

protein kinase, AMP-activated, beta 1 non-catalytic subunit

IDBP-584030

protein kinase, AMP-activated, beta 1 non-catalytic subunit

IDBP-587827

protein kinase, AMP-activated, beta 1 non-catalytic subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:119667753-119681630

Strand

Forward strand

Band

q24.23

Transcripts

ENST00000229328	ENSP00000229328
ENST00000541640	ENSP00000441369
ENST00000537400	ENSP00000444816
ENST00000540121	ENSP00000439235
ENST00000545223	ENSP00000437993
ENST00000545870
ENST00000542698
ENST00000538271
ENST00000537057

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	40 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004679	AMP-activated protein kinase activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006633	fatty acid biosynthetic process
GO:0007050	cell cycle arrest
GO:0007165	signal transduction
GO:0008286	insulin receptor signaling pathway
GO:0010628	positive regulation of gene expression
GO:0050790	regulation of catalytic activity
GO:0051291	protein heterooligomerization
GO:0061024	membrane organization