InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PPP1CA

Summary

InnateDB Gene

IDBG-60210.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PPP1CA

Gene Name

protein phosphatase 1, catalytic subunit, alpha isozyme

Synonyms

PP-1A; PP1A; PP1alpha; PPP1A

Species

Homo sapiens

Ensembl Gene

ENSG00000172531

Encoded Proteins

IDBP-60212

protein phosphatase 1, catalytic subunit, alpha isozyme

IDBP-60214

protein phosphatase 1, catalytic subunit, alpha isozyme

IDBP-60216

protein phosphatase 1, catalytic subunit, alpha isozyme

IDBP-602944

protein phosphatase 1, catalytic subunit, alpha isozyme

IDBP-591666

protein phosphatase 1, catalytic subunit, alpha isozyme

IDBP-597436

protein phosphatase 1, catalytic subunit, alpha isozyme

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18949366

PPP1CA positively regulates the TNF-alpha-induced NF-kappaB pathway at the level of IKK activation.

PMID 23499489

PPP1CA dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.

InnateDB Annotation from Orthologs

Summary

PMID 23499489

[Mus musculus] PPP1CA dephosphorylates RNA sensors, RIG-I (DDX58) and MDA5 (IFIH1), to induce anti-viral IFNB production.

Entrez Gene

Summary

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:67398183-67421183

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000312989	ENSP00000326031
ENST00000376745	ENSP00000365936
ENST00000358239	ENSP00000350974
ENST00000532446
ENST00000526510
ENST00000532279
ENST00000527663	ENSP00000431146
ENST00000537694
ENST00000529724
ENST00000546202	ENSP00000439568
ENST00000542876	ENSP00000438409

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 355 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	355 [view]
Protein-Protein	352 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0016791	phosphatase activity
GO:0043021	ribonucleoprotein complex binding
GO:0046872	metal ion binding

Biological Process

GO:0005977	glycogen metabolic process
GO:0005979	regulation of glycogen biosynthetic process
GO:0005981	regulation of glycogen catabolic process
GO:0006470	protein dephosphorylation
GO:0007049	cell cycle
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016311	dephosphorylation
GO:0019433	triglyceride catabolic process
GO:0030324	lung development
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032922	circadian regulation of gene expression
GO:0042752	regulation of circadian rhythm
GO:0043153	entrainment of circadian clock by photoperiod
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048754	branching morphogenesis of an epithelial tube
GO:0051301	cell division
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0000164	protein phosphatase type 1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0042587	glycogen granule
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043204	perikaryon
GO:0070062	extracellular vesicular exosome
GO:0070688	MLL5-L complex
GO:0072357	PTW/PP1 phosphatase complex