Homo sapiens Gene: RPLP0
Summary
InnateDB Gene IDBG-60241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPLP0
Gene Name ribosomal protein, large, P0
Synonyms L10E; LP0; P0; PRLP0; RPP0;
Species Homo sapiens
Ensembl Gene ENSG00000089157
Encoded Proteins
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
ribosomal protein, large, P0
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which is the functional equivalent of the E. coli L10 ribosomal protein, belongs to the L10P family of ribosomal proteins. It is a neutral phosphoprotein with a C-terminal end that is nearly identical to the C-terminal ends of the acidic ribosomal phosphoproteins P1 and P2. The P0 protein can interact with P1 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Transcript variants derived from alternative splicing exist; they encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:120196686-120201235
Strand Reverse strand
Band q24.23
Transcripts
ENST00000228306 ENSP00000339027
ENST00000313104 ENSP00000366471
ENST00000392514 ENSP00000376299
ENST00000551217
ENST00000551150 ENSP00000449328
ENST00000552292 ENSP00000446777
ENST00000546989 ENSP00000449205
ENST00000552461
ENST00000549098 ENSP00000448919
ENST00000551258 ENSP00000448639
ENST00000546990 ENSP00000447311
ENST00000547475 ENSP00000450222
ENST00000547211 ENSP00000449854
ENST00000547173 ENSP00000450019
ENST00000550856 ENSP00000448046
ENST00000548568
ENST00000546564
ENST00000547191 ENSP00000450121
ENST00000550296
ENST00000552902
ENST00000548495
ENST00000550423 ENSP00000449765
ENST00000551914 ENSP00000448223
ENST00000548551
ENST00000549242
ENST00000551783
ENST00000551336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
Experimentally validated
Total 151 [view]
Protein-Protein 151 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0042254 ribosome biogenesis
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
EGFR1 pathway
REACTOME
Eukaryotic Translation Initiation pathway
Influenza Infection pathway
SRP-dependent cotranslational protein targeting to membrane pathway
Nonsense-Mediated Decay (NMD) pathway
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
Formation of a pool of free 40S subunits pathway
Influenza Viral RNA Transcription and Replication pathway
Translation pathway
Eukaryotic Translation Termination pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Eukaryotic Translation Elongation pathway
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
Influenza Life Cycle pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Viral mRNA Translation pathway
Peptide chain elongation pathway
L13a-mediated translational silencing of Ceruloplasmin expression pathway
Gene Expression pathway
Disease pathway
KEGG
Ribosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL G3V210
UniProt Splice Variant
Entrez Gene 6175
UniGene Hs.674049 Hs.729957 Hs.743734
RefSeq NM_001002 NM_053275
HUGO HGNC:10371
OMIM 180510
CCDS CCDS9193
HPRD 01610
IMGT
EMBL AC004263 CH471054
GenPept EAW98172
RNA Seq Atlas 6175