Homo sapiens Gene: AGTR1
Summary
InnateDB Gene IDBG-60289.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGTR1
Gene Name angiotensin II receptor, type 1
Synonyms AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R;
Species Homo sapiens
Ensembl Gene ENSG00000144891
Encoded Proteins
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
angiotensin II receptor, type 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:148697784-148743008
Strand Forward strand
Band q24
Transcripts
ENST00000349243 ENSP00000273430
ENST00000402260 ENSP00000385641
ENST00000404754 ENSP00000385612
ENST00000418473 ENSP00000398832
ENST00000497524 ENSP00000419422
ENST00000475166
ENST00000475347 ENSP00000419783
ENST00000474935 ENSP00000418084
ENST00000461609 ENSP00000418851
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 22 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001596 angiotensin type I receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004945 angiotensin type II receptor activity
GO:0005515 protein binding
GO:0031711 bradykinin receptor binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001558 regulation of cell growth
GO:0001822 kidney development
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002034 regulation of blood vessel size by renin-angiotensin
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007266 Rho protein signal transduction
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0010873 positive regulation of cholesterol esterification
GO:0019229 regulation of vasoconstriction
GO:0019722 calcium-mediated signaling
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032430 positive regulation of phospholipase A2 activity
GO:0033864 positive regulation of NAD(P)H oxidase activity
GO:0034374 low-density lipoprotein particle remodeling
GO:0035813 regulation of renal sodium excretion
GO:0038166 angiotensin-activated signaling pathway
GO:0042127 regulation of cell proliferation
GO:0042312 regulation of vasodilation
GO:0050727 regulation of inflammatory response
GO:0050729 positive regulation of inflammatory response
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326 cell chemotaxis
GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway
GO:2000379 positive regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
KEGG
Calcium signaling pathway pathway
Neuroactive ligand-receptor interaction pathway
Vascular smooth muscle contraction pathway
Renin-angiotensin system pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling [Biocarta view]
PID NCI
Angiopoietin receptor Tie2-mediated signaling
Arf6 trafficking events
Arf6 signaling events
Cross-References
SwissProt P30556
TrEMBL D3DNG8 Q13063 Q53YY0
UniProt Splice Variant
Entrez Gene 185
UniGene Hs.477887 Hs.734649 Hs.740357
RefSeq NM_000685 NM_004835 NM_009585 NM_031850 NM_032049
HUGO HGNC:336
OMIM 106165
CCDS CCDS3137
HPRD
IMGT
EMBL AF245699 AK291541 AY221090 AY436325 BC022447 CH471052 D13814 EU332837 M87290 M91464 M93394 S77410 S80194 S80239 X65699 Z11162
GenPept AAA35535 AAA35569 AAA58370 AAB34644 AAB35647 AAF70464 AAH22447 AAO65968 AAR03503 ABY87526 BAA02968 BAF84230 CAA46621 CAA77513 EAW78905 EAW78906 EAW78907 EAW78909
RNA Seq Atlas 185