InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AGTR1

Summary

InnateDB Gene

IDBG-60289.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AGTR1

Gene Name

angiotensin II receptor, type 1

Synonyms

AG2S; AGTR1B; AT1; AT1AR; AT1B; AT1BR; AT1R; AT2R1; HAT1R

Species

Homo sapiens

Ensembl Gene

ENSG00000144891

Encoded Proteins

IDBP-60291

angiotensin II receptor, type 1

IDBP-294246

angiotensin II receptor, type 1

IDBP-294257

angiotensin II receptor, type 1

IDBP-365534

angiotensin II receptor, type 1

IDBP-480918

angiotensin II receptor, type 1

IDBP-479196

angiotensin II receptor, type 1

IDBP-478748

angiotensin II receptor, type 1

IDBP-474792

angiotensin II receptor, type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:148697784-148743008

Strand

Forward strand

Band

q24

Transcripts

ENST00000349243	ENSP00000273430
ENST00000402260	ENSP00000385641
ENST00000404754	ENSP00000385612
ENST00000418473	ENSP00000398832
ENST00000497524	ENSP00000419422
ENST00000475166
ENST00000475347	ENSP00000419783
ENST00000474935	ENSP00000418084
ENST00000461609	ENSP00000418851

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001596	angiotensin type I receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004945	angiotensin type II receptor activity
GO:0005515	protein binding
GO:0031711	bradykinin receptor binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001822	kidney development
GO:0002018	renin-angiotensin regulation of aldosterone production
GO:0002034	regulation of blood vessel size by renin-angiotensin
GO:0003081	regulation of systemic arterial blood pressure by renin-angiotensin
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007266	Rho protein signal transduction
GO:0010744	positive regulation of macrophage derived foam cell differentiation
GO:0010873	positive regulation of cholesterol esterification
GO:0019229	regulation of vasoconstriction
GO:0019722	calcium-mediated signaling
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032430	positive regulation of phospholipase A2 activity
GO:0033864	positive regulation of NAD(P)H oxidase activity
GO:0034374	low-density lipoprotein particle remodeling
GO:0035813	regulation of renal sodium excretion
GO:0038166	angiotensin-activated signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042312	regulation of vasodilation
GO:0050727	regulation of inflammatory response
GO:0050729	positive regulation of inflammatory response
GO:0051482	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
GO:0060326	cell chemotaxis
GO:0086097	phospholipase C-activating angiotensin-activated signaling pathway
GO:2000379	positive regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000049115

View Gene Order

ENSBTAG00000045633

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04614

Renin-angiotensin system pathway

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

hsa04270

Vascular smooth muscle contraction pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

angiopoietinreceptor_pathway

Angiopoietin receptor Tie2-mediated signaling

arf6_traffickingpathway

Arf6 trafficking events

arf6_pathway

Arf6 signaling events

Cross-References

SwissProt

P30556

TrEMBL

D3DNG8 Q13063 Q53YY0

UniProt Splice Variant

Entrez Gene

185

UniGene

Hs.477887 Hs.734649 Hs.740357

RefSeq

NM_000685 NM_004835 NM_009585 NM_031850 NM_032049

HUGO

HGNC:336

OMIM

106165

CCDS

CCDS3137

HPRD

IMGT

EMBL

AF245699 AK291541 AY221090 AY436325 BC022447 CH471052 D13814 EU332837 M87290 M91464 M93394 S77410 S80194 S80239 X65699 Z11162

GenPept

AAA35535 AAA35569 AAA58370 AAB34644 AAB35647 AAF70464 AAH22447 AAO65968 AAR03503 ABY87526 BAA02968 BAF84230 CAA46621 CAA77513 EAW78905 EAW78906 EAW78907 EAW78909

RNA Seq Atlas

185