Version 5.4
Mus musculus Gene: Tnnc1
Summary
InnateDB Gene IDBG-606240.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tnnc1
Gene Name troponin C, cardiac/slow skeletal
Synonyms AI874626; cTnC; cTnI; TnC; tncc
Species Mus musculus
Ensembl Gene ENSMUSG00000091898
Encoded Proteins
IDBP-624572
troponin C, cardiac/slow skeletal
IDBP-624575
troponin C, cardiac/slow skeletal
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114854:
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:31208312-31211729
Strand Forward strand
Band B
Transcripts
ENSMUST00000161399
ENSMUST00000169169 ENSMUSP00000131991
ENSMUST00000170268 ENSMUSP00000128765
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0031013 troponin I binding
GO:0031014 troponin T binding
GO:0042803 protein homodimerization activity
GO:0048306 calcium-dependent protein binding
GO:0051015 actin filament binding
Biological Process
GO:0002086 diaphragm contraction
GO:0006937 regulation of muscle contraction
GO:0010038 response to metal ion
GO:0032972 regulation of muscle filament sliding speed
GO:0043462 regulation of ATPase activity
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0060048 cardiac muscle contraction
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005861 troponin complex
GO:0015629 actin cytoskeleton
GO:0043292 contractile fiber
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000114854
View Gene Order
ENSBTAG00000045757
Not yet available
Pathways
NETPATH
REACTOME
REACT_232053
Striated Muscle Contraction pathway
REACT_262759
Muscle contraction pathway
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04260
Cardiac muscle contraction pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
mmu05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16969
Striated Muscle Contraction pathway
REACT_17044
Muscle contraction pathway
REACT_213099
Muscle contraction pathway
REACT_223821
Striated Muscle Contraction pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa04260
Cardiac muscle contraction pathway
hsa05414
Dilated cardiomyopathy pathway
INOH
PID NCI
Cross-References
SwissProt P19123
TrEMBL E9Q8P0
UniProt Splice Variant
Entrez Gene 21924
UniGene
RefSeq NM_009393
OMIM
CCDS CCDS36854
HPRD
IMGT
MGI ID MGI:98779
MGI Symbol Tnnc1
EMBL AC108416 BC061172 J04971 M29793
GenPept AAA37492 AAA37493 AAH61172
RNA Seq Atlas 21924

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca