Version 5.4
Homo sapiens Gene: HNRNPAB
Summary
InnateDB Gene IDBG-60841.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HNRNPAB
Gene Name heterogeneous nuclear ribonucleoprotein A/B
Synonyms ABBP1; HNRPAB
Species Homo sapiens
Ensembl Gene ENSG00000197451
Encoded Proteins
IDBP-60843
heterogeneous nuclear ribonucleoprotein A/B
IDBP-60847
heterogeneous nuclear ribonucleoprotein A/B
IDBP-480900
heterogeneous nuclear ribonucleoprotein A/B
IDBP-484227
heterogeneous nuclear ribonucleoprotein A/B
IDBP-479879
heterogeneous nuclear ribonucleoprotein A/B
IDBP-477043
heterogeneous nuclear ribonucleoprotein A/B
IDBP-473671
heterogeneous nuclear ribonucleoprotein A/B
IDBP-807128
heterogeneous nuclear ribonucleoprotein A/B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and are components of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene, which binds to one of the components of the multiprotein editosome complex, has two repeats of quasi-RRM (RNA recognition motif) domains that bind to RNAs. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:178204507-178211180
Strand Forward strand
Band q35.3
Transcripts
ENST00000358344 ENSP00000351108
ENST00000355836 ENSP00000348093
ENST00000506339 ENSP00000422501
ENST00000514633 ENSP00000427110
ENST00000515193 ENSP00000423495
ENST00000506259 ENSP00000427465
ENST00000504898 ENSP00000425031
ENST00000504796
ENST00000615932 ENSP00000482908
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0043565 sequence-specific DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001837 epithelial to mesenchymal transition
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020358
View Gene Order
ENSBTAG00000013627
Not yet available
Cross-References
SwissProt
TrEMBL D6R9P3
UniProt Splice Variant
Entrez Gene 3182
UniGene Hs.591731
RefSeq NM_004499 NM_031266
HUGO HGNC:5034
OMIM 602688
CCDS CCDS34309 CCDS34310
HPRD 04067
IMGT
EMBL AC136632
GenPept
RNA Seq Atlas 3182

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca