Homo sapiens Gene: UNC93B1
Summary
InnateDB Gene IDBG-61027.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UNC93B1
Gene Name unc-93 homolog B1 (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000110057
Encoded Proteins
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
unc-93 homolog B1 (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
UNC93B1 is a polytopic membrane protein that delivers the nucleotide sensing receptors TLR7 and TLR9 from the endoplasmic reticulum to endolysosomes.
UNC93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing.
UNC93B1 associates with Toll-Like Receptor (TLR) 3, TLR7 and TLR9, mediating their translocation from the endoplasmic reticulum to the endolysosome, hence allowing proper activation by nucleic acid ligands. UNC93B1 has a critical role on induction of IL-12/IFN-gamma production as well as autonomous control of Toxoplasma replication by macrophages.
UNC93B1 controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in UNC93B1 causes TLR7-dependent systemic lethal inflammation. (Demonstrated in murine model)
UNC93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic TLR7 activation by balancing TLR9 to TLR7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.
UNC93B1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs).
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Unc93b1 is a resident endoplasmic reticulum protein that interacts with Tlr11 to regulate the dendritic cell activation in response to T. gondii profilin and parasitic infection.
[Mus musculus] Unc93b1 controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking from endoplasmic reticulum to endolysosomes. D34A mutation in Unc93b1 causes Tlr7-dependent systemic lethal inflammation.
[Mus musculus] Unc93B1 is a multitransmembrane endoplasmic reticulum (ER)-resident protein that controls homeostatic Tlr7 activation by balancing Tlr9 to Tlr7 trafficking. Mice harboring a D34A mutation in Unc93b1 show Tlr7-dependent, systemic lethal inflammation.
[Mus musculus] Unc93b1 participates in intracellular trafficking and signalling for all nucleotide-sensing Toll-like receptors (TLRs ). (Demonstrated in human)
Entrez Gene
Summary This gene encodes a protein with similarity to the C. elegans unc93 protein. The Unc93 protein is involved in the regulation or coordination of muscle contraction in the worm. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67991104-68004982
Strand Reverse strand
Band q13.2
Transcripts
ENST00000227471 ENSP00000227471
ENST00000525368
ENST00000533424
ENST00000524455 ENSP00000434294
ENST00000528423 ENSP00000437195
ENST00000528096
ENST00000530138
ENST00000531152 ENSP00000436758
ENST00000610659
ENST00000622364
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 38 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0035325 Toll-like receptor binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006886 intracellular protein transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034154 toll-like receptor 7 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0032009 early phagosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Trafficking and processing of endosomal TLR pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502989 Hs.568937
RefSeq NM_030930
HUGO
OMIM
CCDS CCDS73334
HPRD 12191
IMGT
EMBL
GenPept
RNA Seq Atlas