Homo sapiens Gene: BUB1B
Summary
InnateDB Gene IDBG-6103.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BUB1B
Gene Name budding uninhibited by benzimidazoles 1 homolog beta (yeast)
Synonyms Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1;
Species Homo sapiens
Ensembl Gene ENSG00000156970
Encoded Proteins
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
budding uninhibited by benzimidazoles 1 homolog beta (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40161023-40221136
Strand Forward strand
Band q15.1
Transcripts
ENST00000287598 ENSP00000287598
ENST00000412359 ENSP00000398470
ENST00000560120
ENST00000559414
ENST00000558715 ENSP00000453861
ENST00000559733 ENSP00000453643
ENST00000559461
ENST00000557848
ENST00000559772
ENST00000558972
ENST00000558151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 118 [view]
Protein-Protein 115 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000278 mitotic cell cycle
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007051 spindle organization
GO:0007067 mitotic nuclear division
GO:0007091 metaphase/anaphase transition of mitotic cell cycle
GO:0007093 mitotic cell cycle checkpoint
GO:0007094 mitotic spindle assembly checkpoint
GO:0008283 cell proliferation
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034501 protein localization to kinetochore
GO:0048015 phosphatidylinositol-mediated signaling
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0071459 protein localization to chromosome, centromeric region
Cellular Component
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0000778 condensed nuclear chromosome kinetochore
GO:0000940 condensed chromosome outer kinetochore
GO:0005680 anaphase-promoting complex
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0048471 perinuclear region of cytoplasm
GO:0051233 spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
APC/C-mediated degradation of cell cycle proteins pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Separation of Sister Chromatids pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Mitotic Spindle Checkpoint pathway
M Phase pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Resolution of Sister Chromatid Cohesion pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001211
HUGO
OMIM
CCDS CCDS10053
HPRD 04176
IMGT
EMBL
GenPept
RNA Seq Atlas