Version 5.4
Homo sapiens Gene: EIF2A
Summary
InnateDB Gene IDBG-61199.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2A
Gene Name eukaryotic translation initiation factor 2A, 65kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000144895
Encoded Proteins
IDBP-61201
eukaryotic translation initiation factor 2A, 65kDa
IDBP-294185
eukaryotic translation initiation factor 2A, 65kDa
IDBP-477792
eukaryotic translation initiation factor 2A, 65kDa
IDBP-480848
eukaryotic translation initiation factor 2A, 65kDa
IDBP-483398
eukaryotic translation initiation factor 2A, 65kDa
IDBP-479639
eukaryotic translation initiation factor 2A, 65kDa
IDBP-477135
eukaryotic translation initiation factor 2A, 65kDa
IDBP-484346
eukaryotic translation initiation factor 2A, 65kDa
IDBP-477079
eukaryotic translation initiation factor 2A, 65kDa
IDBP-479004
eukaryotic translation initiation factor 2A, 65kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes (Zoll et al., 2002 [PubMed 12133843]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:150546678-150584242
Strand Forward strand
Band q25.1
Transcripts
ENST00000273435 ENSP00000273435
ENST00000406576 ENSP00000385292
ENST00000463863
ENST00000487799 ENSP00000420537
ENST00000460851 ENSP00000417229
ENST00000473499
ENST00000494558 ENSP00000419456
ENST00000474505
ENST00000482093 ENSP00000418698
ENST00000469331
ENST00000490505 ENSP00000417575
ENST00000462221 ENSP00000420495
ENST00000477551 ENSP00000420493
ENST00000472926
ENST00000465535 ENSP00000420611
ENST00000482471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0006417 regulation of translation
GO:0006468 protein phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0032933 SREBP signaling pathway
GO:0042255 ribosome assembly
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005850 eukaryotic translation initiation factor 2 complex
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027810
View Gene Order
ENSBTAG00000009106
Not yet available
Pathways
NETPATH
NetPath_18
IL6 pathway
REACTOME
KEGG
INOH
PID NCI
tgfbrpathway
TGF-beta receptor signaling
Cross-References
SwissProt
TrEMBL F8WF18
UniProt Splice Variant
Entrez Gene 83939
UniGene Hs.655782
RefSeq NM_032025
HUGO HGNC:3254
OMIM 609234
CCDS CCDS46935
HPRD 11739
IMGT
EMBL AC107426
GenPept
RNA Seq Atlas 83939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca