Homo sapiens Gene: RUVBL2
Summary
InnateDB Gene IDBG-61221.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RUVBL2
Gene Name RuvB-like 2 (E. coli)
Synonyms ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B;
Species Homo sapiens
Ensembl Gene ENSG00000183207
Encoded Proteins
RuvB-like 2 (E. coli)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:48993448-49015995
Strand Forward strand
Band q13.33
Transcripts
ENST00000221413 ENSP00000221413
ENST00000594338
ENST00000601968 ENSP00000471524
ENST00000595002
ENST00000596247 ENSP00000471538
ENST00000598768
ENST00000596837 ENSP00000469189
ENST00000593570 ENSP00000469488
ENST00000595090 ENSP00000473172
ENST00000595811 ENSP00000469760
ENST00000594017
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 240 [view]
Protein-Protein 237 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003678 DNA helicase activity
GO:0003684 damaged DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0031490 chromatin DNA binding
GO:0042802 identical protein binding
GO:0043141 ATP-dependent 5'-3' DNA helicase activity
GO:0051082 unfolded protein binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006325 chromatin organization
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006457 protein folding
GO:0032508 DNA duplex unwinding
GO:0034644 cellular response to UV
GO:0035066 positive regulation of histone acetylation
GO:0040008 regulation of growth
GO:0043967 histone H4 acetylation
GO:0043968 histone H2A acetylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071169 establishment of protein localization to chromatin
GO:0071392 cellular response to estradiol stimulus
GO:0071733 transcriptional activation by promoter-enhancer looping
GO:0071899 negative regulation of estrogen receptor binding
Cellular Component
GO:0000812 Swr1 complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005719 nuclear euchromatin
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030529 ribonucleoprotein complex
GO:0031011 Ino80 complex
GO:0035267 NuA4 histone acetyltransferase complex
GO:0070062 extracellular vesicular exosome
GO:0071339 MLL1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
HATs acetylate histones pathway
Chromosome Maintenance pathway
Telomere Maintenance pathway
Cell Cycle pathway
Telomere Extension By Telomerase pathway
Chromatin organization pathway
Chromatin modifying enzymes pathway
Extension of Telomeres pathway
KEGG
INOH
PID BIOCARTA
PID NCI
ATF-2 transcription factor network
Validated targets of C-MYC transcriptional activation
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
C-MYC pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.515846
RefSeq NM_006666 XM_005258426 XM_005258427 XM_005258428
HUGO
OMIM
CCDS CCDS42588
HPRD 16070
IMGT
EMBL
GenPept
RNA Seq Atlas