InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RUVBL2

Summary

InnateDB Gene

IDBG-61221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RUVBL2

Gene Name

RuvB-like 2 (E. coli)

Synonyms

ECP51; INO80J; REPTIN; RVB2; TIH2; TIP48; TIP49B

Species

Homo sapiens

Ensembl Gene

ENSG00000183207

Encoded Proteins

IDBP-61223

RuvB-like 2 (E. coli)

IDBP-765944

IDBP-760229

IDBP-765062

IDBP-763246

IDBP-761175

IDBP-761382

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48993448-49015995

Strand

Forward strand

Band

q13.33

Transcripts

ENST00000221413	ENSP00000221413
ENST00000594338
ENST00000601968	ENSP00000471524
ENST00000595002
ENST00000596247	ENSP00000471538
ENST00000598768
ENST00000596837	ENSP00000469189
ENST00000593570	ENSP00000469488
ENST00000595090	ENSP00000473172
ENST00000595811	ENSP00000469760
ENST00000594017

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 239 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	240 [view]
Protein-Protein	237 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003678	DNA helicase activity
GO:0003684	damaged DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0031490	chromatin DNA binding
GO:0042802	identical protein binding
GO:0043141	ATP-dependent 5'-3' DNA helicase activity
GO:0051082	unfolded protein binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006457	protein folding
GO:0032508	DNA duplex unwinding
GO:0034644	cellular response to UV
GO:0035066	positive regulation of histone acetylation
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071169	establishment of protein localization to chromatin
GO:0071392	cellular response to estradiol stimulus
GO:0071733	transcriptional activation by promoter-enhancer looping
GO:0071899	negative regulation of estrogen receptor binding

Cellular Component

GO:0000812	Swr1 complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005719	nuclear euchromatin
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016363	nuclear matrix
GO:0030529	ribonucleoprotein complex
GO:0031011	Ino80 complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0070062	extracellular vesicular exosome
GO:0071339	MLL1 complex