Homo sapiens Gene: CANX
Summary
InnateDB Gene IDBG-61587.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CANX
Gene Name calnexin
Synonyms CNX; IP90; P90;
Species Homo sapiens
Ensembl Gene ENSG00000127022
Encoded Proteins
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
calnexin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:179678628-179730925
Strand Forward strand
Band q35.3
Transcripts
ENST00000247461 ENSP00000247461
ENST00000452673 ENSP00000391646
ENST00000514383 ENSP00000424341
ENST00000502296 ENSP00000424745
ENST00000504734 ENSP00000424063
ENST00000502498 ENSP00000425246
ENST00000507307 ENSP00000426052
ENST00000504579 ENSP00000426425
ENST00000513246 ENSP00000421813
ENST00000502673 ENSP00000421107
ENST00000506654 ENSP00000426555
ENST00000514032 ENSP00000427115
ENST00000510810 ENSP00000424740
ENST00000509563 ENSP00000421434
ENST00000503126
ENST00000508787 ENSP00000424140
ENST00000506298
ENST00000505090
ENST00000503303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 125 [view]
Protein-Protein 124 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0034185 apolipoprotein binding
GO:0035255 ionotropic glutamate receptor binding
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006457 protein folding
GO:0007568 aging
GO:0009306 protein secretion
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048488 synaptic vesicle endocytosis
GO:0061077 chaperone-mediated protein folding
GO:0072583 clathrin-mediated endocytosis
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005790 smooth endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005840 ribosome
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030424 axon
GO:0032839 dendrite cytoplasm
GO:0042470 melanosome
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
GO:0071556 integral component of lumenal side of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
MHC class II antigen presentation pathway
Calnexin/calreticulin cycle pathway
Influenza Infection pathway
Assembly of Viral Components at the Budding Site pathway
Post-translational protein modification pathway
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
Asparagine N-linked glycosylation pathway
Virus Assembly and Release pathway
Metabolism of proteins pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
Influenza Life Cycle pathway
N-glycan trimming in the ER and Calnexin/Calreticulin cycle pathway
Disease pathway
KEGG
Protein processing in endoplasmic reticulum pathway
Phagosome pathway
Antigen processing and presentation pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.567968
RefSeq NM_001024649 NM_001746
HUGO
OMIM
CCDS CCDS4447
HPRD 00252
IMGT
EMBL
GenPept
RNA Seq Atlas