InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MAML1

Summary

InnateDB Gene

IDBG-61656.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAML1

Gene Name

mastermind-like 1 (Drosophila)

Synonyms

Mam-1; Mam1

Species

Homo sapiens

Ensembl Gene

ENSG00000161021

Encoded Proteins

IDBP-61658

mastermind-like 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:179732850-179796511

Strand

Forward strand

Band

q35.3

Transcripts

ENST00000292599	ENSP00000292599
ENST00000503050
ENST00000507385
ENST00000511027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	22 [view]
Protein-Protein	21 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042605	peptide antigen binding

Biological Process

GO:0003162	atrioventricular node development
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0007219	Notch signaling pathway
GO:0010467	gene expression
GO:0010831	positive regulation of myotube differentiation
GO:0045445	myoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051149	positive regulation of muscle cell differentiation
GO:0060928	atrioventricular node cell development

Cellular Component

GO:0002193	MAML1-RBP-Jkappa- ICN1 complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016607	nuclear speck
GO:0043231	intracellular membrane-bounded organelle