Homo sapiens Gene: TIMP1
Summary
InnateDB Gene IDBG-61666.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TIMP1
Gene Name TIMP metallopeptidase inhibitor 1
Synonyms CLGI; EPA; EPO; HCI; TIMP;
Species Homo sapiens
Ensembl Gene ENSG00000102265
Encoded Proteins
TIMP metallopeptidase inhibitor 1
TIMP metallopeptidase inhibitor 1
TIMP metallopeptidase inhibitor 1
TIMP metallopeptidase inhibitor 1
TIMP metallopeptidase inhibitor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:47582313-47586789
Strand Forward strand
Band p11.3
Transcripts
ENST00000218388 ENSP00000218388
ENST00000377017 ENSP00000366216
ENST00000456754 ENSP00000406671
ENST00000441738 ENSP00000405380
ENST00000445623 ENSP00000410983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0001775 cell activation
GO:0002576 platelet degranulation
GO:0007568 aging
GO:0007596 blood coagulation
GO:0008284 positive regulation of cell proliferation
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0022617 extracellular matrix disassembly
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0048553 negative regulation of metalloenzyme activity
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:1901164 negative regulation of trophoblast cell migration
GO:2001044 regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Activation of Matrix Metalloproteinases pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Hemostasis pathway
KEGG
INOH
PID BIOCARTA
Inhibition of matrix metalloproteinases [Biocarta view]
PID NCI
AP-1 transcription factor network
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_003254 XM_005272645
HUGO
OMIM
CCDS CCDS14281
HPRD 02371
IMGT
EMBL
GenPept
RNA Seq Atlas