InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TIMP1

Summary

InnateDB Gene

IDBG-61666.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TIMP1

Gene Name

TIMP metallopeptidase inhibitor 1

Synonyms

CLGI; EPA; EPO; HCI; TIMP

Species

Homo sapiens

Ensembl Gene

ENSG00000102265

Encoded Proteins

IDBP-61668

TIMP metallopeptidase inhibitor 1

IDBP-61672

TIMP metallopeptidase inhibitor 1

IDBP-369458

TIMP metallopeptidase inhibitor 1

IDBP-369471

TIMP metallopeptidase inhibitor 1

IDBP-369483

TIMP metallopeptidase inhibitor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:47582313-47586789

Strand

Forward strand

Band

p11.3

Transcripts

ENST00000218388	ENSP00000218388
ENST00000377017	ENSP00000366216
ENST00000456754	ENSP00000406671
ENST00000441738	ENSP00000405380
ENST00000445623	ENSP00000410983

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	15 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005125	cytokine activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0008191	metalloendopeptidase inhibitor activity
GO:0046872	metal ion binding

Biological Process

GO:0001775	cell activation
GO:0002576	platelet degranulation
GO:0007568	aging
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010951	negative regulation of endopeptidase activity
GO:0022617	extracellular matrix disassembly
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034097	response to cytokine
GO:0042060	wound healing
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0048553	negative regulation of metalloenzyme activity
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:1901164	negative regulation of trophoblast cell migration
GO:2001044	regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0031012	extracellular matrix
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome