Homo sapiens Gene: BMI1
Summary
InnateDB Gene IDBG-61688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMI1
Gene Name BMI1 polycomb ring finger oncogene
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000168283
Encoded Proteins
BMI1 polycomb ring finger oncogene
BMI1 polycomb ring finger oncogene
BMI1 polycomb ring finger oncogene
BMI1 polycomb ring finger oncogene
BMI1 polycomb ring finger oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:22321211-22331484
Strand Forward strand
Band p12.2
Transcripts
ENST00000376663 ENSP00000365851
ENST00000417470 ENSP00000398759
ENST00000442508 ENSP00000397912
ENST00000456675
ENST00000416820 ENSP00000399220
ENST00000443519 ENSP00000390768
ENST00000496174
ENST00000490311
ENST00000602523
ENST00000602358
ENST00000602524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 413 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 413 [view]
Protein-Protein 411 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0071535 RING-like zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007379 segment specification
GO:0010468 regulation of gene expression
GO:0016568 chromatin modification
GO:0030097 hemopoiesis
GO:0048146 positive regulation of fibroblast proliferation
GO:0051443 positive regulation of ubiquitin-protein transferase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0031519 PcG protein complex
GO:0035102 PRC1 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Cellular Senescence pathway
Oxidative Stress Induced Senescence pathway
KEGG
INOH
PID BIOCARTA
The prc2 complex sets long-term gene silencing through modification of histone tails [Biocarta view]
PID NCI
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.380403
RefSeq NM_005180 NM_001204062
HUGO
OMIM
CCDS CCDS7138 CCDS59213
HPRD 01277
IMGT
EMBL
GenPept
RNA Seq Atlas