Homo sapiens Gene: CCND1
InnateDB Gene IDBG-61868.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCND1
Gene Name cyclin D1
Synonyms BCL1; D11S287E; PRAD1; U21B31
Species Homo sapiens
Ensembl Gene ENSG00000110092
Encoded Proteins
cyclin D1
cyclin D1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69641087-69654474
Strand Forward strand
Band q13.3
ENST00000227507 ENSP00000227507
ENST00000536559 ENSP00000438482
Number of Interactions This gene and/or its encoded proteins are associated with 164 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 164 [view]
Protein-Protein 129 [view]
Protein-DNA 29 [view]
Protein-RNA 3 [view]
DNA-DNA 3 [view]
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0004672 protein kinase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0016301 kinase activity
GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0032403 protein complex binding
GO:0042826 histone deacetylase binding
GO:0070064 proline-rich region binding
Biological Process
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000278 mitotic cell cycle
GO:0000320 re-entry into mitotic cell cycle
GO:0001889 liver development
GO:0001934 positive regulation of protein phosphorylation
GO:0006351 transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006974 cellular response to DNA damage stimulus
GO:0007049 cell cycle
GO:0007219 Notch signaling pathway
GO:0007595 lactation
GO:0008284 positive regulation of cell proliferation
GO:0010033 response to organic substance
GO:0010039 response to iron ion
GO:0010165 response to X-ray
GO:0010243 response to organonitrogen compound
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle
GO:0014070 response to organic cyclic compound
GO:0016055 Wnt signaling pathway
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030857 negative regulation of epithelial cell differentiation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0031100 organ regeneration
GO:0031571 mitotic G1 DNA damage checkpoint
GO:0032026 response to magnesium ion
GO:0033197 response to vitamin E
GO:0033327 Leydig cell differentiation
GO:0033598 mammary gland epithelial cell proliferation
GO:0033601 positive regulation of mammary gland epithelial cell proliferation
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0045444 fat cell differentiation
GO:0045471 response to ethanol
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048545 response to steroid hormone
GO:0051301 cell division
GO:0051384 response to glucocorticoid
GO:0051412 response to corticosterone
GO:0051592 response to calcium ion
GO:0051726 regulation of cell cycle
GO:0060070 canonical Wnt signaling pathway
GO:0060749 mammary gland alveolus development
GO:0070141 response to UV-A
GO:0071157 negative regulation of cell cycle arrest
GO:0071310 cellular response to organic substance
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005923 tight junction
GO:0016020 membrane
GO:0017053 transcriptional repressor complex
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
AndrogenReceptor pathway
TGF_beta_Receptor pathway
Wnt pathway
Prolactin pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Cyclin D associated events in G1 pathway
Pre-NOTCH Transcription and Translation pathway
G1 Phase pathway
Pre-NOTCH Expression and Processing pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Signal Transduction pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Cell Cycle pathway
Chromatin organization pathway
Signaling by NOTCH pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Cell Cycle, Mitotic pathway
Acute myeloid leukemia pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
Wnt signaling pathway pathway
Cell cycle pathway
Melanoma pathway
Thyroid cancer pathway
Endometrial cancer pathway
Bladder cancer pathway
Glioma pathway
Small cell lung cancer pathway
Prostate cancer pathway
Focal adhesion pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Viral myocarditis pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
E-cadherin signaling in the nascent adherens junction
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Validated nuclear estrogen receptor alpha network
Coregulation of Androgen receptor activity
Presenilin action in Notch and Wnt signaling
Signaling mediated by p38-gamma and p38-delta
ATF-2 transcription factor network
Signaling events mediated by focal adhesion kinase
Validated targets of C-MYC transcriptional repression
Regulation of nuclear beta catenin signaling and target gene transcription
Integrin-linked kinase signaling
AP-1 transcription factor network
Neurotrophic factor-mediated Trk receptor signaling
C-MYB transcription factor network
FOXM1 transcription factor network
Regulation of Telomerase
Notch signaling pathway
UniProt Splice Variant
Entrez Gene
UniGene Hs.523852 Hs.732748
RefSeq NM_053056 XM_006718653
HPRD 01346
RNA Seq Atlas