InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCND1

Summary

InnateDB Gene

IDBG-61868.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCND1

Gene Name

cyclin D1

Synonyms

BCL1; D11S287E; PRAD1; U21B31

Species

Homo sapiens

Ensembl Gene

ENSG00000110092

Encoded Proteins

IDBP-61870

cyclin D1

IDBP-595492

cyclin D1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:69641087-69654474

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000227507	ENSP00000227507
ENST00000539241
ENST00000536559	ENSP00000438482
ENST00000535993
ENST00000545484
ENST00000542367

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 164 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	164 [view]
Protein-Protein	129 [view]
Protein-DNA	29 [view]
Protein-RNA	3 [view]
DNA-DNA	3 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding
GO:0042826	histone deacetylase binding
GO:0070064	proline-rich region binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0000278	mitotic cell cycle
GO:0000320	re-entry into mitotic cell cycle
GO:0001889	liver development
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0007219	Notch signaling pathway
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0010033	response to organic substance
GO:0010039	response to iron ion
GO:0010165	response to X-ray
GO:0010243	response to organonitrogen compound
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle
GO:0014070	response to organic cyclic compound
GO:0016055	Wnt signaling pathway
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030857	negative regulation of epithelial cell differentiation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031100	organ regeneration
GO:0031571	mitotic G1 DNA damage checkpoint
GO:0032026	response to magnesium ion
GO:0033197	response to vitamin E
GO:0033327	Leydig cell differentiation
GO:0033598	mammary gland epithelial cell proliferation
GO:0033601	positive regulation of mammary gland epithelial cell proliferation
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045444	fat cell differentiation
GO:0045471	response to ethanol
GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0048545	response to steroid hormone
GO:0051301	cell division
GO:0051384	response to glucocorticoid
GO:0051412	response to corticosterone
GO:0051592	response to calcium ion
GO:0051726	regulation of cell cycle
GO:0060070	canonical Wnt signaling pathway
GO:0060749	mammary gland alveolus development
GO:0070141	response to UV-A
GO:0071157	negative regulation of cell cycle arrest
GO:0071310	cellular response to organic substance
GO:2000045	regulation of G1/S transition of mitotic cell cycle

Cellular Component

GO:0000307	cyclin-dependent protein kinase holoenzyme complex
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005923	tight junction
GO:0016020	membrane
GO:0017053	transcriptional repressor complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000070348

View Gene Order

ENSBTAG00000017514

Not yet available

Pathways

NETPATH

NetPath_2

AndrogenReceptor pathway

NetPath_7

TGF_beta_Receptor pathway

NetPath_8

Wnt pathway

NetPath_56

Prolactin pathway

REACTOME

REACT_4

Ubiquitin-dependent degradation of Cyclin D1 pathway

REACT_821

Cyclin D associated events in G1 pathway

REACT_118568

Pre-NOTCH Transcription and Translation pathway

REACT_1590

G1 Phase pathway

REACT_118744

Pre-NOTCH Expression and Processing pathway

REACT_21267

Mitotic G1-G1/S phases pathway

REACT_899

S Phase pathway

REACT_111102

Signal Transduction pathway

REACT_938

Ubiquitin-dependent degradation of Cyclin D pathway

REACT_115566

Cell Cycle pathway

REACT_172623

Chromatin organization pathway

REACT_299

Signaling by NOTCH pathway

REACT_228108

RMTs methylate histone arginines pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_152

Cell Cycle, Mitotic pathway

KEGG

hsa05221

Acute myeloid leukemia pathway

hsa05210

Colorectal cancer pathway

hsa05223

Non-small cell lung cancer pathway

hsa04310

Wnt signaling pathway pathway

hsa04110

Cell cycle pathway

hsa05218

Melanoma pathway

hsa05216

Thyroid cancer pathway

hsa05213

Endometrial cancer pathway

hsa05219

Bladder cancer pathway

hsa05214

Glioma pathway

hsa05222

Small cell lung cancer pathway

hsa05215

Prostate cancer pathway

hsa04510

Focal adhesion pathway

hsa04630

Jak-STAT signaling pathway pathway

hsa05220

Chronic myeloid leukemia pathway

hsa05212

Pancreatic cancer pathway

hsa04115

p53 signaling pathway pathway

hsa05200

Pathways in cancer pathway

hsa05416

Viral myocarditis pathway

INOH

PID NCI

pi3kplctrkpathway

Trk receptor signaling mediated by PI3K and PLC-gamma

ecadherin_nascentaj_pathway

E-cadherin signaling in the nascent adherens junction

fra_pathway

Validated transcriptional targets of AP1 family members Fra1 and Fra2

era_genomic_pathway

Validated nuclear estrogen receptor alpha network

ar_pathway

Coregulation of Androgen receptor activity

ps1pathway

Presenilin action in Notch and Wnt signaling

p38gammadeltapathway

Signaling mediated by p38-gamma and p38-delta

atf2_pathway

ATF-2 transcription factor network

fak_pathway

Signaling events mediated by focal adhesion kinase

myc_represspathway

Validated targets of C-MYC transcriptional repression

betacatenin_nuc_pathway

Regulation of nuclear beta catenin signaling and target gene transcription

ilk_pathway

Integrin-linked kinase signaling

ap1_pathway

AP-1 transcription factor network

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

cmyb_pathway

C-MYB transcription factor network

foxm1pathway

FOXM1 transcription factor network

telomerasepathway

Regulation of Telomerase

notch_pathway

Notch signaling pathway

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.523852 Hs.732748

RefSeq

NM_053056 XM_006718653

HUGO

OMIM

CCDS

CCDS8191

HPRD

01346

IMGT

EMBL

GenPept

RNA Seq Atlas