Homo sapiens Gene: CNOT6
Summary
InnateDB Gene IDBG-62304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNOT6
Gene Name CCR4-NOT transcription complex, subunit 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113300
Encoded Proteins
CCR4-NOT transcription complex, subunit 6
CCR4-NOT transcription complex, subunit 6
CCR4-NOT transcription complex, subunit 6
CCR4-NOT transcription complex, subunit 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:180494412-180578405
Strand Forward strand
Band q35.3
Transcripts
ENST00000261951 ENSP00000261951
ENST00000393356 ENSP00000377024
ENST00000510148
ENST00000507016
ENST00000502447
ENST00000504343 ENSP00000422087
ENST00000618123 ENSP00000481893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004532 exoribonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006417 regulation of translation
GO:0008284 positive regulation of cell proliferation
GO:0010467 gene expression
GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035195 gene silencing by miRNA
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000327 positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0016020 membrane
GO:0030014 CCR4-NOT complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Deadenylation-dependent mRNA decay pathway
Deadenylation of mRNA pathway
Gene Expression pathway
KEGG
RNA degradation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_015455 XM_005265953 XM_006714899 XM_006714900
HUGO
OMIM
CCDS CCDS4455
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas