Homo sapiens Gene: CTTN
Summary
InnateDB Gene IDBG-62310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTTN
Gene Name cortactin
Synonyms EMS1;
Species Homo sapiens
Ensembl Gene ENSG00000085733
Encoded Proteins
cortactin
cortactin
cortactin
cortactin
cortactin
cortactin
cortactin
cortactin
cortactin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70398404-70436584
Strand Forward strand
Band q13.3
Transcripts
ENST00000346329 ENSP00000317189
ENST00000301843 ENSP00000301843
ENST00000376561 ENSP00000365745
ENST00000393747 ENSP00000377348
ENST00000415461 ENSP00000409014
ENST00000482755
ENST00000483662
ENST00000498223 ENSP00000434669
ENST00000527622
ENST00000525276
ENST00000532334
ENST00000527962 ENSP00000433552
ENST00000525852
ENST00000529736 ENSP00000431421
ENST00000533931 ENSP00000436613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 137 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
GO:1990023 mitotic spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
Tight junction pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
E-cadherin signaling in the nascent adherens junction
Syndecan-3-mediated signaling events
FGF signaling pathway
PDGFR-beta signaling pathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL H0YCD9
UniProt Splice Variant
Entrez Gene 2017
UniGene Hs.596164
RefSeq NM_138565 NM_005231 NM_001184740 XM_006718448
HUGO HGNC:3338
OMIM 164765
CCDS CCDS8197 CCDS41680 CCDS53676
HPRD 01268
IMGT
EMBL AP000487
GenPept
RNA Seq Atlas 2017