Version 5.4
Homo sapiens Gene: CTTN
Summary
InnateDB Gene IDBG-62310.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTTN
Gene Name cortactin
Synonyms EMS1
Species Homo sapiens
Ensembl Gene ENSG00000085733
Encoded Proteins
IDBP-62312
cortactin
IDBP-62314
cortactin
IDBP-62316
cortactin
IDBP-242989
cortactin
IDBP-380004
cortactin
IDBP-603856
cortactin
IDBP-598990
cortactin
IDBP-591342
cortactin
IDBP-603334
cortactin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:70398404-70436584
Strand Forward strand
Band q13.3
Transcripts
ENST00000346329 ENSP00000317189
ENST00000301843 ENSP00000301843
ENST00000376561 ENSP00000365745
ENST00000393747 ENSP00000377348
ENST00000415461 ENSP00000409014
ENST00000482755
ENST00000483662
ENST00000498223 ENSP00000434669
ENST00000527622
ENST00000525276
ENST00000532334
ENST00000527962 ENSP00000433552
ENST00000525852
ENST00000529736 ENSP00000431421
ENST00000533931 ENSP00000436613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 137 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
GO:1990023 mitotic spindle midzone
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031078
View Gene Order
ENSBTAG00000006071
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04530
Tight junction pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
syndecan_3_pathway
Syndecan-3-mediated signaling events
fgf_pathway
FGF signaling pathway
pdgfrbpathway
PDGFR-beta signaling pathway
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596164
RefSeq NM_001184740 NM_005231 NM_138565 XM_006718448
HUGO
OMIM
CCDS CCDS41680 CCDS53676 CCDS8197
HPRD 01268
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca