Version 5.4
Bos taurus Gene: ING2
Summary
InnateDB Gene IDBG-628502.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ING2
Gene Name inhibitor of growth protein 2
Synonyms INGX
Species Bos taurus
Ensembl Gene ENSBTAG00000047706
Encoded Proteins
IDBP-679866
inhibitor of growth family, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168556:
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. [provided by RefSeq, Jul 2008]
This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 27:13339706-13346831
Strand Forward strand
Band
Transcripts
ENSBTAT00000066213 ENSBTAP00000054457
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0032403 protein complex binding
GO:0035064 methylated histone binding
GO:0035091 phosphatidylinositol binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007141 male meiosis I
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0008285 negative regulation of cell proliferation
GO:0016568 chromatin modification
GO:0030317 sperm motility
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048133 male germ-line stem cell division
GO:0072520 seminiferous tubule development
GO:2001234 negative regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0016580 Sin3 complex
GO:0016602 CCAAT-binding factor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000168556
View Gene Order
ENSMUSG00000063049
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3MY31
UniProt Splice Variant
Entrez Gene 404141
UniGene Bt.15313
RefSeq NM_001193225
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02060155
GenPept
RNA Seq Atlas 404141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca