Version 5.4
Bos taurus Gene: DST
Summary
InnateDB Gene IDBG-628621.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DST
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021237
Encoded Proteins
IDBP-680064
dystonin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151914:
This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been reported that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 23:3431407-3687495
Strand Forward strand
Band
Transcripts
ENSBTAT00000061451 ENSBTAP00000053548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0007050 cell cycle arrest
GO:0007409 axonogenesis
GO:0008090 retrograde axon cargo transport
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031122 cytoplasmic microtubule organization
Cellular Component
GO:0005856 cytoskeleton
GO:0015629 actin cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0030056 hemidesmosome
GO:0060053 neurofilament cytoskeleton
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000151914
View Gene Order
ENSMUSG00000026131
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
REACTOME
REACT_20537
Type I hemidesmosome assembly pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
KEGG
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.110669 Bt.111172
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca