InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCM1

Summary

InnateDB Gene

IDBG-628634.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCM1

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007236

Encoded Proteins

IDBP-680016

pericentriolar material 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000078674:
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:18328847-18405603

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000061016

ENSBTAP00000053719

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0022027	interkinetic nuclear migration
GO:0031122	cytoplasmic microtubule organization
GO:0034453	microtubule anchoring
GO:0034454	microtubule anchoring at centrosome
GO:0035735	intraciliary transport involved in cilium morphogenesis
GO:0042384	cilium assembly
GO:0050768	negative regulation of neurogenesis
GO:0051297	centrosome organization
GO:0071539	protein localization to centrosome
GO:0090316	positive regulation of intracellular protein transport
GO:0097150	neuronal stem cell maintenance

Cellular Component

GO:0000242	pericentriolar material
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0031965	nuclear membrane
GO:0034451	centriolar satellite
GO:0036064	ciliary basal body
GO:0043234	protein complex