InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OCLN

Summary

InnateDB Gene

IDBG-628655.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OCLN

Gene Name

occludin

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000561

Encoded Proteins

IDBP-680025

occludin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000197822:
This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5. [provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:10154909-10201157

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000734

ENSBTAP00000000734

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0019904	protein domain specific binding

Biological Process

GO:0045216	cell-cell junction organization
GO:0070830	tight junction assembly

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030054	cell junction
GO:0030139	endocytic vesicle
GO:0031410	cytoplasmic vesicle