InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IGF1R

Summary

InnateDB Gene

IDBG-628659.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF1R

Gene Name

Insulin-like growth factor 1 receptor Insulin-like growth factor 1 receptor alpha chain Insulin-like growth factor 1 receptor beta chain

Synonyms

IGFR1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000021527

Encoded Proteins

IDBP-680055

Insulin-like growth factor 1 receptorInsulin-like growth factor 1 receptor alpha chainInsulin-like growth factor 1 receptor beta chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 10747872

[Homo sapiens] IGF1R is able to mediate activation of STAT3 in vitro and in vivo and the JAKs are essential for this process of activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140443:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq, Jul 2008]
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:8208822-8268093

Strand

Forward strand

Band

Transcripts

ENSBTAT00000028690

ENSBTAP00000028690

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.

Predicted by orthology
Total	53 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005010	insulin-like growth factor-activated receptor activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031994	insulin-like growth factor I binding
GO:0042802	identical protein binding
GO:0043548	phosphatidylinositol 3-kinase binding
GO:0043559	insulin binding
GO:0043560	insulin receptor substrate binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006955	immune response
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007420	brain development
GO:0008544	epidermis development
GO:0009887	organ morphogenesis
GO:0016310	phosphorylation
GO:0030238	male sex determination
GO:0030335	positive regulation of cell migration
GO:0030879	mammary gland development
GO:0031017	exocrine pancreas development
GO:0038083	peptidyl-tyrosine autophosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0043409	negative regulation of MAPK cascade
GO:0043410	positive regulation of MAPK cascade
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045740	positive regulation of DNA replication
GO:0045840	positive regulation of mitosis
GO:0046328	regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048009	insulin-like growth factor receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051262	protein tetramerization
GO:0051389	inactivation of MAPKK activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0051898	negative regulation of protein kinase B signaling
GO:0060740	prostate gland epithelium morphogenesis

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043235	receptor complex