Bos taurus Gene: BT.22214 | |||||||
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Summary | |||||||
InnateDB Gene | IDBG-628694.3 | ||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
Gene Symbol | BT.22214 | ||||||
Gene Name | CD180 antigen precursor | ||||||
Synonyms | |||||||
Species | Bos taurus | ||||||
Ensembl Gene | ENSBTAG00000006360 | ||||||
Encoded Proteins |
CD180 antigen
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Protein Structure | |||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||
InnateDB Annotation from Orthologs | |||||||
Summary |
[Homo sapiens] CD180 is an accessory molecule for TLR2, forming part of the receptor complex for innate immune recognition of mycobacterial lipoproteins.
[Homo sapiens] CD180 and its helper molecule, LY86, interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligands.
[Homo sapiens] CD180 dramatically enhances CpG DNA-induced proliferation/survival by naive B cells but not by memory B cell. This enhancement that is mediated by CD180-induced TLR9 upregulation, leading to Akt activation and sustained NF-kappaB activation.
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Entrez Gene | |||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134061:
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||
Type | Protein coding | ||||||
Genomic Location | Chromosome 20:12352171-12366624 | ||||||
Strand | Forward strand | ||||||
Band | |||||||
Transcripts |
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Interactions | |||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||
NETPATH | |||||||
REACTOME |
Toll Like Receptor 4 (TLR4) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
Innate Immune System pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG | |||||||
INOH | |||||||
PID NCI | |||||||
Cross-References | |||||||
SwissProt | |||||||
TrEMBL | |||||||
UniProt Splice Variant | |||||||
Entrez Gene | |||||||
UniGene | Bt.22214 | ||||||
RefSeq | NM_001076168 XM_005221460 | ||||||
HUGO | |||||||
OMIM | |||||||
CCDS | |||||||
HPRD | |||||||
IMGT | |||||||
EMBL | |||||||
GenPept | |||||||
RNA Seq Atlas | |||||||