InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CNOT7

Summary

InnateDB Gene

IDBG-628698.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT7

Gene Name

CCR4-NOT transcription complex subunit 7

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018036

Encoded Proteins

IDBP-680071

CCR4-NOT transcription complex subunit 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198791:
The protein encoded by this gene binds to an anti-proliferative protein, B-cell translocation protein 1, which negatively regulates cell proliferation. Binding of the two proteins, which is driven by phosphorylation of the anti-proliferative protein, causes signaling events in cell division that lead to changes in cell proliferation associated with cell-cell contact. The protein has both mouse and yeast orthologs. Alternate splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:19052444-19067489

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024009

ENSBTAP00000024009

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000175	3'-5'-exoribonuclease activity
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0004518	nuclease activity
GO:0004527	exonuclease activity
GO:0004532	exoribonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

Biological Process

GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0031047	gene silencing by RNA
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay