InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RET

Summary

InnateDB Gene

IDBG-628722.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RET

Gene Name

proto-oncogene tyrosine-protein kinase receptor Ret precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000570

Encoded Proteins

IDBP-680127

ret proto-oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165731:
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:13562993-13615888

Strand

Forward strand

Band

Transcripts

ENSBTAT00000000744

ENSBTAP00000000744

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001755	neural crest cell migration
GO:0001838	embryonic epithelial tube formation
GO:0006468	protein phosphorylation
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007156	homophilic cell adhesion
GO:0007158	neuron cell-cell adhesion
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007399	nervous system development
GO:0010976	positive regulation of neuron projection development
GO:0016310	phosphorylation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030155	regulation of cell adhesion
GO:0030182	neuron differentiation
GO:0030335	positive regulation of cell migration
GO:0033619	membrane protein proteolysis
GO:0033630	positive regulation of cell adhesion mediated by integrin
GO:0035799	ureter maturation
GO:0042551	neuron maturation
GO:0045793	positive regulation of cell size
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048265	response to pain
GO:0048484	enteric nervous system development
GO:0050770	regulation of axonogenesis
GO:0061146	Peyer's patch morphogenesis
GO:0071300	cellular response to retinoic acid
GO:0072300	positive regulation of metanephric glomerulus development
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex