Version 5.4
Bos taurus Gene: TNFSF11
Summary
InnateDB Gene IDBG-628731.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNFSF11
Gene Name tumor necrosis factor ligand superfamily member 11
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000008924
Encoded Proteins
IDBP-680111
tumor necrosis factor (ligand) superfamily, member 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 21566133
[Homo sapiens] TLR2 and TNFSF11 signalling pathways are modulated by Porphromonas gingivalis to alter the differentiation states of osteoclasts resulting in bacteria-mediated bone loss. (Demonstrated in murine model)
PMID 21566133
[Mus musculus] Tlr2 and Tnfsf11 signalling pathways are modulated by Porphromonas gingivalis to alter the differentiation states of osteoclasts resulting in bacteria-mediated bone loss.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120659:
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:12741069-12782474
Strand Forward strand
Band
Transcripts
ENSBTAT00000011745 ENSBTAP00000011745
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005164 tumor necrosis factor receptor binding
GO:0005515 protein binding
GO:0032813 tumor necrosis factor receptor superfamily binding
Biological Process
GO:0001503 ossification
GO:0002158 osteoclast proliferation
GO:0002548 monocyte chemotaxis
GO:0006955 immune response
GO:0007257 activation of JUN kinase activity
GO:0009887 organ morphogenesis
GO:0019221 cytokine-mediated signaling pathway
GO:0030316 osteoclast differentiation
GO:0033209 tumor necrosis factor-mediated signaling pathway
GO:0033598 mammary gland epithelial cell proliferation
GO:0034112 positive regulation of homotypic cell-cell adhesion
GO:0042327 positive regulation of phosphorylation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043406 positive regulation of MAP kinase activity
GO:0045453 bone resorption
GO:0045670 regulation of osteoclast differentiation
GO:0045672 positive regulation of osteoclast differentiation
GO:0045780 positive regulation of bone resorption
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046330 positive regulation of JNK cascade
GO:0050870 positive regulation of T cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051260 protein homooligomerization
GO:0051466 positive regulation of corticotropin-releasing hormone secretion
GO:0051897 positive regulation of protein kinase B signaling
GO:0055074 calcium ion homeostasis
GO:0060749 mammary gland alveolus development
GO:0070371 ERK1 and ERK2 cascade
GO:0071812 positive regulation of fever generation by positive regulation of prostaglandin secretion
GO:0071847 TNFSF11-mediated signaling pathway
GO:0071848 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling
GO:1902533 positive regulation of intracellular signal transduction
GO:2001206 positive regulation of osteoclast development
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120659
View Gene Order
ENSMUSG00000022015
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_21
RANKL pathway
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04380
Osteoclast differentiation pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
il6_7pathway
IL6-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.112393
RefSeq NM_001205770
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca