Bos taurus Gene: FGB | |||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-628961.3 | ||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
Gene Symbol | FGB | ||||||||||||||||||||||||||||||
Gene Name | fibrinogen beta chain precursor | ||||||||||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000022120 | ||||||||||||||||||||||||||||||
Encoded Proteins |
fibrinogen beta chain
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Protein Structure | |||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171564:
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008] The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014] |
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Gene Information | |||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||
Genomic Location | Chromosome 17:2875550-2884552 | ||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||
Band | |||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||
REACTOME |
Common Pathway pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
Platelet degranulation pathway
Response to elevated platelet cytosolic Ca2+ pathway
Integrin cell surface interactions pathway
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Hemostasis pathway
Platelet degranulation pathway
Hemostasis pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Integrin cell surface interactions pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Response to elevated platelet cytosolic Ca2+ pathway
Common Pathway pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Platelet Aggregation (Plug Formation) pathway
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KEGG |
Complement and coagulation cascades pathway
Complement and coagulation cascades pathway
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INOH | |||||||||||||||||||||||||||||||
PID NCI |
Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta3 integrin cell surface interactions
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Cross-References | |||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||
TrEMBL | A6QPX7 F1MAV0 | ||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||
Entrez Gene | 510522 | ||||||||||||||||||||||||||||||
UniGene | Bt.23917 | ||||||||||||||||||||||||||||||
RefSeq | NM_001142917 XM_005217435 | ||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||
EMBL | BC149541 DAAA02044108 | ||||||||||||||||||||||||||||||
GenPept | AAI49542 | ||||||||||||||||||||||||||||||
RNA Seq Atlas | 510522 | ||||||||||||||||||||||||||||||