InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAXX

Summary

InnateDB Gene

IDBG-629026.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAXX

Gene Name

death domain-associated protein 6

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016830

Encoded Proteins

IDBP-680415

death domain-associated protein 6

IDBP-680421

death domain-associated protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 24550390

[Mus musculus] Daxx interacts with Hdac1 and represses the transcription of Il6 in TLR-triggered macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204209:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 23:7429817-7434186

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000022388	ENSBTAP00000022388
ENSBTAT00000036227	ENSBTAP00000036089

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 90 interaction(s) predicted by orthology.

Predicted by orthology
Total	90 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030295	protein kinase activator activity
GO:0031625	ubiquitin protein ligase binding
GO:0042393	histone binding
GO:0042803	protein homodimerization activity
GO:0047485	protein N-terminus binding
GO:0050681	androgen receptor binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0001934	positive regulation of protein phosphorylation
GO:0006334	nucleosome assembly
GO:0006338	chromatin remodeling
GO:0006355	regulation of transcription, DNA-templated
GO:0030521	androgen receptor signaling pathway
GO:0031396	regulation of protein ubiquitination
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0097190	apoptotic signaling pathway
GO:1901216	positive regulation of neuron death
GO:2001235	positive regulation of apoptotic signaling pathway