Version 5.4
Bos taurus Gene: ITM2B
Summary
InnateDB Gene IDBG-629079.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITM2B
Gene Name integral membrane protein 2B
Synonyms Bri; imBRI2
Species Bos taurus
Ensembl Gene ENSBTAG00000003109
Encoded Proteins
IDBP-680467
integral membrane protein 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136156:
Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18114553-18139506
Strand Forward strand
Band
Transcripts
ENSBTAT00000004044 ENSBTAP00000004044
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030660 Golgi-associated vesicle membrane
GO:0031301 integral component of organelle membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136156
View Gene Order
ENSMUSG00000022108
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
REACTOME
REACT_75925
Amyloids pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_198563
Amyloids pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001035093
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca