Version 5.4
Bos taurus Gene: BT.68871
Summary
InnateDB Gene IDBG-629082.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.68871
Gene Name retinoblastoma-associated protein
Synonyms P105-RB; PP110; RB11
Species Bos taurus
Ensembl Gene ENSBTAG00000006640
Encoded Proteins
IDBP-680475
retinoblastoma-associated protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 22310660
[Homo sapiens] RB1 positively regulates TLR3 expression by modulating the transcription factor E2F1. (Demonstrated in mice)
PMID 22310660
[Mus musculus] Rb1 positively regulates Tlr3 expression by modulating the transcription factor E2f1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139687:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:18196465-18316589
Strand Forward strand
Band
Transcripts
ENSBTAT00000008728 ENSBTAP00000008728
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 226 interaction(s) predicted by orthology.
Predicted by orthology
Total 226 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0001102 RNA polymerase II activating transcription factor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006469 negative regulation of protein kinase activity
GO:0007050 cell cycle arrest
GO:0007265 Ras protein signal transduction
GO:0007346 regulation of mitotic cell cycle
GO:0008285 negative regulation of cell proliferation
GO:0030182 neuron differentiation
GO:0031134 sister chromatid biorientation
GO:0031175 neuron projection development
GO:0034088 maintenance of mitotic sister chromatid cohesion
GO:0034349 glial cell apoptotic process
GO:0035914 skeletal muscle cell differentiation
GO:0042551 neuron maturation
GO:0043353 enucleate erythrocyte differentiation
GO:0043550 regulation of lipid kinase activity
GO:0045445 myoblast differentiation
GO:0045651 positive regulation of macrophage differentiation
GO:0045786 negative regulation of cell cycle
GO:0045842 positive regulation of mitotic metaphase/anaphase transition
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048565 digestive tract development
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0051146 striated muscle cell differentiation
GO:0051301 cell division
GO:0051402 neuron apoptotic process
GO:0051726 regulation of cell cycle
GO:0071459 protein localization to chromosome, centromeric region
GO:0071922 regulation of cohesin localization to chromatin
GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0097284 hepatocyte apoptotic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005819 spindle
GO:0016605 PML body
GO:0035189 Rb-E2F complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139687
View Gene Order
ENSMUSG00000022105
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_5
ID pathway
NetPath_7
TGF_beta_Receptor pathway
NetPath_9
TNFalpha pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_15
IL3 pathway
NetPath_18
IL6 pathway
NetPath_23
TSH pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_308
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_383
DNA Replication pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_2014
Synthesis of DNA pathway
REACT_172744
Condensation of Prophase Chromosomes pathway
REACT_169121
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_1783
G1/S Transition pathway
REACT_115566
Cell Cycle pathway
REACT_169185
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_765
Mitotic Prophase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_829
Regulation of DNA replication pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_258062
Synthesis of DNA pathway
REACT_208887
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_232628
DNA Replication pathway
REACT_262530
Switching of origins to a post-replicative state pathway
REACT_188957
Cellular responses to stress pathway
REACT_223647
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_196580
Condensation of Prophase Chromosomes pathway
REACT_219010
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
REACT_255479
Regulation of DNA replication pathway
REACT_188820
Cellular Senescence pathway
REACT_245230
Orc1 removal from chromatin pathway
REACT_253002
G1/S Transition pathway
REACT_236939
Removal of licensing factors from origins pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
REACT_206830
E2F mediated regulation of DNA replication pathway
REACT_250557
Mitotic Prophase pathway
REACT_245868
Cyclin E associated events during G1/S transition pathway
REACT_253623
S Phase pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
mmu05219
Bladder cancer pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
p53downstreampathway
Direct p53 effectors
atf2_pathway
ATF-2 transcription factor network
hes_heypathway
Notch-mediated HES/HEY network
p73pathway
p73 transcription factor network
e2f_pathway
E2F transcription factor network
foxm1pathway
FOXM1 transcription factor network
Cross-References
SwissProt
TrEMBL F1MD46
UniProt Splice Variant
Entrez Gene 534712
UniGene Bt.47780 Bt.68871
RefSeq NM_001076907
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02032882 DAAA02032883 DAAA02032884 DAAA02032885
GenPept
RNA Seq Atlas 534712

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca