Bos taurus Gene: COL1A2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-629088.3 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | COL1A2 | ||||||||||||||||||||||
Gene Name | Collagen alpha-2(I) chain | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Bos taurus | ||||||||||||||||||||||
Ensembl Gene | ENSBTAG00000013472 | ||||||||||||||||||||||
Encoded Proteins |
Collagen alpha-2(I) chain
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164692:
This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 4:11624470-11661163 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | |||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Collagen formation pathway
Cell surface interactions at the vascular wall pathway
Non-integrin membrane-ECM interactions pathway
Collagen biosynthesis and modifying enzymes pathway
Extracellular matrix organization pathway
Collagen degradation pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Degradation of the extracellular matrix pathway
Assembly of collagen fibrils and other multimeric structures pathway
Scavenging by Class A Receptors pathway
Anchoring fibril formation pathway
GPVI-mediated activation cascade pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Integrin cell surface interactions pathway
Crosslinking of collagen fibrils pathway
Platelet Adhesion to exposed collagen pathway
ECM proteoglycans pathway
Syndecan interactions pathway
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KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cell surface interactions at the vascular wall pathway
Platelet Adhesion to exposed collagen pathway
GPVI-mediated activation cascade pathway
Integrin cell surface interactions pathway
Anchoring fibril formation pathway
Crosslinking of collagen fibrils pathway
Assembly of collagen fibrils and other multimeric structures pathway
Collagen biosynthesis and modifying enzymes pathway
Collagen degradation pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
Syndecan interactions pathway
Platelet activation, signaling and aggregation pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Collagen formation pathway
Hemostasis pathway
Collagen formation pathway
Assembly of collagen fibrils and other multimeric structures pathway
Syndecan interactions pathway
Hemostasis pathway
Collagen biosynthesis and modifying enzymes pathway
Cell surface interactions at the vascular wall pathway
Anchoring fibril formation pathway
Extracellular matrix organization pathway
Platelet activation, signaling and aggregation pathway
Binding and Uptake of Ligands by Scavenger Receptors pathway
Scavenging by Class A Receptors pathway
Platelet Adhesion to exposed collagen pathway
GPVI-mediated activation cascade pathway
Integrin cell surface interactions pathway
ECM proteoglycans pathway
Non-integrin membrane-ECM interactions pathway
Crosslinking of collagen fibrils pathway
Degradation of the extracellular matrix pathway
Collagen degradation pathway
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KEGG |
ECM-receptor interaction pathway
Focal adhesion pathway
Amoebiasis pathway
Protein digestion and absorption pathway
ECM-receptor interaction pathway
Focal adhesion pathway
Amoebiasis pathway
Protein digestion and absorption pathway
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INOH |
Integrin signaling pathway pathway
Integrin signaling pathway pathway
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PID NCI |
Beta1 integrin cell surface interactions
Validated transcriptional targets of AP1 family members Fra1 and Fra2
VEGFR3 signaling in lymphatic endothelium
Validated targets of C-MYC transcriptional repression
AP-1 transcription factor network
Endothelins
C-MYB transcription factor network
IL4-mediated signaling events
Regulation of nuclear SMAD2/3 signaling
Beta3 integrin cell surface interactions
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Bt.53485 Bt.67532 | ||||||||||||||||||||||
RefSeq | NM_174520 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | |||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||