Bos taurus Gene: BIRC3 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-629168.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BIRC3 | ||||||||||||||||
Gene Name | baculoviral IAP repeat-containing protein 3 | ||||||||||||||||
Synonyms | BIRC2 | ||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000024918 | ||||||||||||||||
Encoded Proteins |
baculoviral IAP repeat-containing protein 3
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
InnateDB Annotation from Orthologs | |||||||||||||||||
Summary |
[Homo sapiens] BIRC3 is required for proper RIPK1 polyubiquitination and NF-kappaB activation upon TNF (TNF-alpha) treatment and regulates TNF-mediated NF-kappaB activation by binding to TNFRSF1A (TNFR1).
[Homo sapiens] BIRC3 and BIRC2 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.
[Mus musculus] Birc3 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
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Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023445:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 15:6639728-6654015 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME |
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
NOD1/2 Signaling Pathway pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
Immune System pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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KEGG |
Apoptosis pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Focal adhesion pathway
Pathways in cancer pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Apoptosis pathway
Focal adhesion pathway
Pathways in cancer pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
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INOH | |||||||||||||||||
PID NCI |
CD40/CD40L signaling
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | |||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | |||||||||||||||||
UniGene | |||||||||||||||||
RefSeq | |||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | |||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | |||||||||||||||||