InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: WWOX

Summary

InnateDB Gene

IDBG-629302.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WWOX

Gene Name

WW domain-containing oxidoreductase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015894

Encoded Proteins

IDBP-680715

WW domain-containing oxidoreductase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186153:
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:5283909-6196774

Strand

Forward strand

Band

Transcripts

ENSBTAT00000032617

ENSBTAP00000032547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0019899	enzyme binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0008152	metabolic process
GO:0030178	negative regulation of Wnt signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048705	skeletal system morphogenesis
GO:0055114	oxidation-reduction process
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator
GO:0097191	extrinsic apoptotic signaling pathway
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway
GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand