InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HMGB2

Summary

InnateDB Gene

IDBG-629304.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HMGB2

Gene Name

High mobility group protein B2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000015101

Encoded Proteins

IDBP-680703

High mobility group protein B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19890330

[Homo sapiens] HMGB2 functions as a universal sentinel for nucleic-acid-mediated innate immune responses.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164104:
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:5583684-5586018

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000020096

ENSBTAP00000020096

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.

Predicted by orthology
Total	25 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003697	single-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008301	DNA binding, bending
GO:0042056	chemoattractant activity
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0006265	DNA topological change
GO:0006288	base-excision repair, DNA ligation
GO:0006310	DNA recombination
GO:0006338	chromatin remodeling
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0032075	positive regulation of nuclease activity
GO:0033151	V(D)J recombination
GO:0043388	positive regulation of DNA binding
GO:0045648	positive regulation of erythrocyte differentiation
GO:0045654	positive regulation of megakaryocyte differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050918	positive chemotaxis
GO:0060326	cell chemotaxis
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0000793	condensed chromosome
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005694	chromosome
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm