InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SMAD1

Summary

InnateDB Gene

IDBG-629431.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD1

Gene Name

Mothers against decapentaplegic homolog 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002835

Encoded Proteins

IDBP-680838

Mothers against decapentaplegic homolog 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170365:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene \'mothers against decapentaplegic\' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:12906376-12953417

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003668

ENSBTAP00000003668

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 152 interaction(s) predicted by orthology.

Predicted by orthology
Total	152 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0070410	co-SMAD binding
GO:0070411	I-SMAD binding

Biological Process

GO:0000165	MAPK cascade
GO:0001657	ureteric bud development
GO:0001710	mesodermal cell fate commitment
GO:0002051	osteoblast fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007183	SMAD protein complex assembly
GO:0007276	gamete generation
GO:0008285	negative regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0030901	midbrain development
GO:0030902	hindbrain development
GO:0042592	homeostatic process
GO:0045669	positive regulation of osteoblast differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:0060038	cardiac muscle cell proliferation
GO:0060348	bone development
GO:0061036	positive regulation of cartilage development
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005637	nuclear inner membrane
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0043234	protein complex