InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HK1

Summary

InnateDB Gene

IDBG-629484.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HK1

Gene Name

hexokinase-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012380

Encoded Proteins

IDBP-680927

hexokinase 1

IDBP-680931

hexokinase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000156515:
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:25854741-25925054

Strand

Forward strand

Band

Transcripts

ENSBTAT00000047248	ENSBTAP00000044468
ENSBTAT00000016432	ENSBTAP00000016432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004340	glucokinase activity
GO:0004396	hexokinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0019158	mannokinase activity

Biological Process

GO:0001678	cellular glucose homeostasis
GO:0005975	carbohydrate metabolic process
GO:0006096	glycolytic process
GO:0016310	phosphorylation
GO:0046835	carbohydrate phosphorylation
GO:0051156	glucose 6-phosphate metabolic process