InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: RNF43

Summary

InnateDB Gene

IDBG-629509.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RNF43

Gene Name

RING finger protein 43 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000020119

Encoded Proteins

IDBP-680923

ring finger protein 43

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108375:
RNF43 is a HAP95 (AKAP8L; MIM 609475) binding ubiquitin ligase that promotes cell growth and is upregulated in colon cancer (Yagyu et al., 2004 [PubMed 15492824]; Sugiura et al., 2008 [PubMed 18313049]).[supplied by OMIM, Dec 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:9548268-9612348

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000026797

ENSBTAP00000026797

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005109	frizzled binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Biological Process

GO:0007165	signal transduction
GO:0016567	protein ubiquitination
GO:0030178	negative regulation of Wnt signaling pathway
GO:0038018	Wnt receptor catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089	stem cell proliferation