Version 5.4
Bos taurus Gene: LGR5
Summary
InnateDB Gene IDBG-629611.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LGR5
Gene Name leucine-rich repeat-containing G-protein coupled receptor 5 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000013256
Encoded Proteins
IDBP-681017
leucine-rich repeat containing G protein-coupled receptor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000139292:
Gene Information
Type Protein coding
Genomic Location Chromosome 5:1076799-1203289
Strand Forward strand
Band
Transcripts
ENSBTAT00000017631 ENSBTAP00000017631
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0048839 inner ear development
GO:0090263 positive regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000139292
View Gene Order
ENSMUSG00000020140
View Gene Order
Pathways
NETPATH
REACTOME
REACT_212636
Signaling by Wnt pathway
REACT_242703
Signaling by WNT in cancer pathway
REACT_217918
TCF dependent signaling in response to WNT pathway
REACT_234280
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_225047
regulation of FZD by ubiquitination pathway
REACT_242720
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_214353
Signal Transduction pathway
REACT_236591
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207087
Disease pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_111102
Signal Transduction pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_116125
Disease pathway
REACT_189085
Disease pathway
REACT_214014
Signaling by Wnt pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_213035
regulation of FZD by ubiquitination pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_188257
Signal Transduction pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt F1MT22
TrEMBL
UniProt Splice Variant
Entrez Gene 520189
UniGene Bt.94743
RefSeq NM_001192520
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02012284 DAAA02012285 DAAA02012286 DAAA02012287 DAAA02012288
GenPept
RNA Seq Atlas 520189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca