Version 5.4
Bos taurus Gene: GHR
Summary
InnateDB Gene IDBG-629685.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GHR
Gene Name growth hormone receptor precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000001335
Encoded Proteins
IDBP-681108
growth hormone receptor precursor
IDBP-681112
growth hormone receptor precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112964:
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:31890736-32199996
Strand Reverse strand
Band
Transcripts
ENSBTAT00000001758 ENSBTAP00000001758
ENSBTAT00000036771 ENSBTAP00000036626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004896 cytokine receptor activity
GO:0004903 growth hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0019838 growth factor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0019221 cytokine-mediated signaling pathway
GO:0031623 receptor internalization
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0040018 positive regulation of multicellular organism growth
GO:0044236 multicellular organismal metabolic process
GO:0046898 response to cycloheximide
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0060396 growth hormone receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0043235 receptor complex
GO:0070195 growth hormone receptor complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000112964
View Gene Order
ENSMUSG00000055737
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_198574
Nuclear signaling by ERBB4 pathway
REACT_198561
Prolactin receptor signaling pathway
REACT_188579
Signaling by ERBB4 pathway
REACT_233584
Cytokine Signaling in Immune system pathway
REACT_230745
Immune System pathway
REACT_198614
Growth hormone receptor signaling pathway
REACT_188257
Signal Transduction pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04080
Neuroactive ligand-receptor interaction pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL B3VHT8 F1MQ39 Q2Q9Z4 Q6DUF3
UniProt Splice Variant
Entrez Gene 280805
UniGene Bt.79147
RefSeq NM_176608
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AAFC03001528 AAFC03001530 AAFC03033137 AAFC03033138 AAFC03033139 AAFC03033140 AAFC03033141 AAFC03034555 AAFC03042485 AAFC03042486 AAFC03119051 AY643807 DQ168854 DQ168855 DQ168856 DQ168857 DQ168860 EU747321 JQ711177
GenPept AAT65182 ABA70591 ABA70592 ABA70593 ABA70594 ABA70597 ACE62925 AFN44371
RNA Seq Atlas 280805

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca