Version 5.4
Bos taurus Gene: C6
Summary
InnateDB Gene IDBG-629747.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C6
Gene Name complement component C6 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014177
Encoded Proteins
IDBP-681164
complement component C6 precursor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 11058761
[Homo sapiens] Complement component six is one of five components that interact to form the cytolytic membrane attack complex (MAC)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000039537:
This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:33328558-33405555
Strand Forward strand
Band
Transcripts
ENSBTAT00000018845 ENSBTAP00000018845
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006955 immune response
Cellular Component
GO:0005579 membrane attack complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000039537
View Gene Order
ENSMUSG00000022181
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_8028
Terminal pathway of complement pathway
REACT_118707
Regulation of Complement cascade pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_6932
Complement cascade pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
hsa05322
Systemic lupus erythematosus pathway
hsa05020
Prion diseases pathway
mmu04610
Complement and coagulation cascades pathway
mmu05322
Systemic lupus erythematosus pathway
mmu05020
Prion diseases pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.17116
RefSeq NM_001045979 XM_005221546
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca