InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.21975

Summary

InnateDB Gene

IDBG-629772.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.21975

Gene Name

perforin-1 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001008

Encoded Proteins

IDBP-681185

perforin-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000180644:
The protein encoded by this gene has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. This protein is one of the main cytolytic proteins of cytolytic granules, and it is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:26939280-26941721

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000001336

ENSBTAP00000001336

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0022829	wide pore channel activity

Biological Process

GO:0002357	defense response to tumor cell
GO:0002418	immune response to tumor cell
GO:0019835	cytolysis
GO:0051260	protein homooligomerization
GO:0051607	defense response to virus
GO:0055085	transmembrane transport