InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PCBD1

Summary

InnateDB Gene

IDBG-629809.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCBD1

Gene Name

Pterin-4-alpha-carbinolamine dehydratase

Synonyms

DCoH; PCD; PHS

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011866

Encoded Proteins

IDBP-681234

Pterin-4-alpha-carbinolamine dehydratase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000166228:
This gene encodes pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerization of the transcription factor hepatocyte nuclear factor 1 (HNF1). [provided by RefSeq, Jul 2008]
This gene encodes a member of the pterin-4-alpha-carbinolamine dehydratase family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The encoded protein functions as both a dehydratase involved in tetrahydrobiopterin biosynthesis, and as a cofactor for HNF1A-dependent transcription. A deficiency of this enzyme leads to hyperphenylalaninemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 28:27226795-27231724

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000015750

ENSBTAP00000015750

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 86 interaction(s) predicted by orthology.

Predicted by orthology
Total	86 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004505	phenylalanine 4-monooxygenase activity
GO:0005515	protein binding
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity
GO:0016829	lyase activity
GO:0042802	identical protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006729	tetrahydrobiopterin biosynthetic process
GO:0051289	protein homotetramerization
GO:0051291	protein heterooligomerization
GO:0055114	oxidation-reduction process