Version 5.4
Bos taurus Gene: ACAT1
Summary
InnateDB Gene IDBG-629836.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAT1
Gene Name Acetyl-CoA acetyltransferase, mitochondrial
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012885
Encoded Proteins
IDBP-681253
Acetyl-CoA acetyltransferase, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000075239:
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:17999932-18028984
Strand Forward strand
Band
Transcripts
ENSBTAT00000017122 ENSBTAP00000017122
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
Predicted by orthology
Total 37 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003985 acetyl-CoA C-acetyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
GO:0046872 metal ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000075239
View Gene Order
ENSMUSG00000032047
View Gene Order
Pathways
NETPATH
REACTOME
REACT_226362
Metabolism of amino acids and derivatives pathway
REACT_212702
Synthesis of Ketone Bodies pathway
REACT_205772
Utilization of Ketone Bodies pathway
REACT_222008
Ketone body metabolism pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_216656
Branched-chain amino acid catabolism pathway
REACT_219139
Metabolism pathway
REACT_226458
Fatty acid, triacylglycerol, and ketone body metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1464
Synthesis of Ketone Bodies pathway
REACT_59
Utilization of Ketone Bodies pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_197
Branched-chain amino acid catabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_1861
Ketone body metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_243038
Synthesis of Ketone Bodies pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_237455
Ketone body metabolism pathway
REACT_248143
Utilization of Ketone Bodies pathway
REACT_254568
Branched-chain amino acid catabolism pathway
KEGG
hsa00900
Terpenoid backbone biosynthesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00280
Valine, leucine and isoleucine degradation pathway
hsa00650
Butanoate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa00630
Glyoxylate and dicarboxylate metabolism pathway
hsa00380
Tryptophan metabolism pathway
hsa00072
Synthesis and degradation of ketone bodies pathway
hsa00071
Fatty acid degradation pathway
hsa00310
Lysine degradation pathway
mmu00280
Valine, leucine and isoleucine degradation pathway
mmu00310
Lysine degradation pathway
mmu00072
Synthesis and degradation of ketone bodies pathway
mmu00900
Terpenoid backbone biosynthesis pathway
mmu00380
Tryptophan metabolism pathway
mmu00640
Propanoate metabolism pathway
mmu00620
Pyruvate metabolism pathway
mmu00650
Butanoate metabolism pathway
mmu00630
Glyoxylate and dicarboxylate metabolism pathway
mmu00071
Fatty acid degradation pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Butanoate metabolism pathway
INOH website
Citrate cycle pathway
INOH website
Pyruvate metabolism pathway
INOH website
Lysine degradation pathway
PID NCI
Cross-References
SwissProt Q29RZ0
TrEMBL
UniProt Splice Variant
Entrez Gene 511082
UniGene Bt.57598
RefSeq NM_001046075
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC113328
GenPept AAI13329
RNA Seq Atlas 511082

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca