InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DAB2

Summary

InnateDB Gene

IDBG-629939.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAB2

Gene Name

disabled homolog 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016152

Encoded Proteins

IDBP-681365

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153071:
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:35018908-35079162

Strand

Forward strand

Band

Transcripts

ENSBTAT00000021501

ENSBTAP00000021501

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 76 interaction(s) predicted by orthology.

Predicted by orthology
Total	76 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	protein C-terminus binding
GO:0030276	clathrin binding
GO:0035091	phosphatidylinositol binding
GO:0035612	AP-2 adaptor complex binding
GO:0035615	clathrin adaptor activity
GO:0038024	cargo receptor activity
GO:0046332	SMAD binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0001701	in utero embryonic development
GO:0001921	positive regulation of receptor recycling
GO:0001934	positive regulation of protein phosphorylation
GO:0006907	pinocytosis
GO:0007257	activation of JUN kinase activity
GO:0007492	endoderm development
GO:0007588	excretion
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0030099	myeloid cell differentiation
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032091	negative regulation of protein binding
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032968	positive regulation of transcription elongation from RNA polymerase II promoter
GO:0043066	negative regulation of apoptotic process
GO:0045785	positive regulation of cell adhesion
GO:0045807	positive regulation of endocytosis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0048268	clathrin coat assembly
GO:0060391	positive regulation of SMAD protein import into nucleus
GO:0060766	negative regulation of androgen receptor signaling pathway
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:2000096	positive regulation of Wnt receptor signaling pathway, planar cell polarity pathway
GO:2000370	positive regulation of clathrin-mediated endocytosis
GO:2000643	positive regulation of early endosome to late endosome transport
GO:2001046	positive regulation of integrin-mediated signaling pathway
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016324	apical plasma membrane
GO:0030132	clathrin coat of coated pit
GO:0043231	intracellular membrane-bounded organelle
GO:0070022	transforming growth factor beta receptor homodimeric complex
GO:0070062	extracellular vesicular exosome