InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: BT.105991

Summary

InnateDB Gene

IDBG-630188.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.105991

Gene Name

DNA topoisomerase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004593

Encoded Proteins

IDBP-681837

DNA topoisomerase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077097:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 27:40005123-40051816

Strand

Forward strand

Band

Transcripts

ENSBTAT00000006030

ENSBTAP00000006030

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003916	DNA topoisomerase activity
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008301	DNA binding, bending
GO:0016853	isomerase activity
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0001764	neuron migration
GO:0006200	ATP catabolic process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change
GO:0006268	DNA unwinding involved in DNA replication
GO:0006312	mitotic recombination
GO:0007409	axonogenesis
GO:0030900	forebrain development
GO:0044774	mitotic DNA integrity checkpoint

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000077097

View Gene Order

ENSMUSG00000017485

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Bt.105991 Bt.109851 Bt.110118 Bt.66356

RefSeq

XM_002698750 XM_005197225 XM_005197226

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas