Version 5.4
Bos taurus Gene: PFDN2
Summary
InnateDB Gene IDBG-630209.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PFDN2
Gene Name Prefoldin subunit 2
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000020152
Encoded Proteins
IDBP-681649
Prefoldin subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000143256:
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:8395605-8407551
Strand Forward strand
Band
Transcripts
ENSBTAT00000026841 ENSBTAP00000026841
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0051086 chaperone mediated protein folding independent of cofactor
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0016272 prefoldin complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000143256
View Gene Order
ENSMUSG00000006412
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223239
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_203284
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_219091
Chaperonin-mediated protein folding pathway
REACT_213782
Metabolism of proteins pathway
REACT_215927
Protein folding pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_247926
Metabolism of proteins pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_245534
Protein folding pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt A1A4P5
TrEMBL Q862M6
UniProt Splice Variant
Entrez Gene 404138
UniGene Bt.1544
RefSeq NM_001080221
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB098954 BC126786
GenPept AAI26787 BAC56444
RNA Seq Atlas 404138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca