Bos taurus Gene: BT.41853 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-630215.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | BT.41853 | ||||||||||||||||
Gene Name | protein phosphatase 1 regulatory subunit 12A | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000014609 | ||||||||||||||||
Encoded Proteins |
protein phosphatase 1, regulatory (inhibitor) subunit 12A
protein phosphatase 1, regulatory (inhibitor) subunit 12A
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000058272:
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 5:9347411-9511533 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
EGFR1 pathway
TNFalpha pathway
TSLP pathway
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REACTOME |
Regulation of PLK1 Activity at G2/M Transition pathway
Cell Cycle pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Mitotic G2-G2/M phases pathway
Regulation of PLK1 Activity at G2/M Transition pathway
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KEGG |
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
Regulation of actin cytoskeleton pathway
Focal adhesion pathway
Vascular smooth muscle contraction pathway
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INOH | |||||||||||||||||
PID NCI |
Integrin-linked kinase signaling
RhoA signaling pathway
PLK1 signaling events
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F1N3L1 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 538606 | ||||||||||||||||
UniGene | Bt.41853 | ||||||||||||||||
RefSeq | NM_001102217 XM_005206032 XM_005206033 | ||||||||||||||||
HUGO | HGNC:7618 | ||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | DAAA02012440 DAAA02012441 DAAA02012442 DAAA02012443 DAAA02012444 DAAA02012445 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 538606 | ||||||||||||||||