Version 5.4
| Bos taurus Gene: SKP2 | |||||||
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| Summary | |||||||
| InnateDB Gene | IDBG-630323.3 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | SKP2 | ||||||
| Gene Name | S-phase kinase-associated protein 2 | ||||||
| Synonyms | |||||||
| Species | Bos taurus | ||||||
| Ensembl Gene | ENSBTAG00000013562 | ||||||
| Encoded Proteins |
S-phase kinase-associated protein 2
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| Protein Structure | |||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||
| InnateDB Annotation from Orthologs | |||||||
| Summary |
[Homo sapiens] IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
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| Entrez Gene | |||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145604:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011] |
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| Gene Information | |||||||
| Type | Protein coding | ||||||
| Genomic Location | Chromosome 20:38078912-38116310 | ||||||
| Strand | Reverse strand | ||||||
| Band | |||||||
| Transcripts |
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| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 111 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||
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Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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| Pathway Predictions based on Human Orthology Data | |||||||
| NETPATH |
Notch pathway
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| REACTOME |
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Cyclin D associated events in G1 pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
G1 Phase pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
G1 Phase pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
Cyclin D associated events in G1 pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Regulation of mitotic cell cycle pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Adaptive Immune System pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S Phase pathway
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| KEGG |
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Small cell lung cancer pathway
Pathways in cancer pathway
Ubiquitin mediated proteolysis pathway
Cell cycle pathway
Small cell lung cancer pathway
Pathways in cancer pathway
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| INOH | |||||||
| PID NCI |
Regulation of retinoblastoma protein
FoxO family signaling
p53 pathway
C-MYC pathway
FOXM1 transcription factor network
Notch signaling pathway
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| Cross-References | |||||||
| SwissProt | |||||||
| TrEMBL | A7MB09 | ||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 785617 | ||||||
| UniGene | Bt.24638 | ||||||
| RefSeq | NM_001102052 XM_003587863 XM_005221600 | ||||||
| HUGO | |||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | BC151275 DAAA02050644 | ||||||
| GenPept | AAI51276 | ||||||
| RNA Seq Atlas | 519018 785617 | ||||||