InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: OCRL

Summary

InnateDB Gene

IDBG-630467.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OCRL

Gene Name

inositol polyphosphate 5-phosphatase OCRL-1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018247

Encoded Proteins

IDBP-681933

inositol polyphosphate 5-phosphatase OCRL-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122126:
This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:13452405-13501004

Strand

Forward strand

Band

Transcripts

ENSBTAT00000024296

ENSBTAP00000024296

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0001701	in utero embryonic development
GO:0007165	signal transduction
GO:0032314	regulation of Rac GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0042384	cilium assembly
GO:0046856	phosphatidylinositol dephosphorylation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0030136	clathrin-coated vesicle
GO:0070062	extracellular vesicular exosome